Nevertheless, there are reports that reduced SETD8 expression levels caused by the polymorphism rs16917496 T>C are associated with a decreased susceptibility to different types of cancer, including breast and ovarian cancer, small cell lung carcinoma (SCLC), hepatocellular carcinoma (HCC), non-small cell lung carcinoma NSCLC, and childhood acute lymphoblastic leukemia (ALL)11. This evidence concerns the gene KMT5A and non-small cell lung carcinoma.