Next, we wanted to further understand the mechanism by which SETD8 regulated angiogenesis, Because, during tumor angiogenesis, several angiogenic stimuli induce the expression of epithelial- mesenchymal transition (EMT) related genes including SNAIL and FIBRONECTIN, we hypothesized that SETD8 may regulates the expression of EMT related genes. The gene discussed is FN1; the disease is neoplasm.