To better visualize the progression of colitis susceptibility in re-PepT1−/− mice compared with re-WT mice across generations from parents (P) to F4, we expressed the various parameters of inflammation as fold-difference in re-PepT1−/− relative to re-WT and plotted all fold-changes for a given inflammatory parameter on the same graph and compared it to the parents (Fig. 5b–e). This evidence concerns the gene SLC15A1 and colitis.