In addition, the phosphorylation of STAT3/5 and EGFR, as well as the expression of total EGFR, PKCα, TRIB3, and core pluripotency factors, were reduced in tumor tissue samples from NCI-H1975 inoculated mice treated with SAH-JGZ4 (Supplementary Fig. 7d, e). The gene discussed is STAT3; the disease is neoplasm.