TRIB3 and lung carcinoma: Because neither the correlation between the mRNA levels of EGFR and TRIB3 from TCGA lung cancer data sets (Supplementary Fig. 1e) nor an effect of TRIB3 depletion on EGFR transcription in A549 cells was detected (Supplementary Fig. 1f), differences in EGFR protein stability were compared between NCI-H157 and A549 cells that showed identical levels of WT-EGFR, but the NCI-H157 cells expressed much less TRIB3 than the A549 cells (Fig. 1a).