Importantly, these effects could be rescued by overexpressing the EGFRT654D mutant but not the EGFRT654A or EGFRT654D/K689R mutants (Supplementary Fig. 4c, d), indicating that TRIB3 promotes NSCLC progression by enhancing PKCα and WWP1-regulated EGFR stability. This evidence concerns the gene EGFR and non-small cell lung carcinoma.