We next examined whether SAH-JGZ4 could sensitize the therapeutic effect of carboplatin or pemetrexed in two NSCLC patient-derived xenograft (PDX) models, which showed higher TRIB3 and EGFR expression than A549 cells (Fig. 8c and Supplementary Fig. 7f). This evidence concerns the gene TRIB3 and non-small cell lung carcinoma.