INS and hepatocellular carcinoma: Altogether these results indicate that, similarly to human HepG2 hepatoma cells, McARH7777 rat and Hepa1-6 mouse hepatoma cells display aberrant post receptor insulin signaling consisting in elevated basal phosphorylation of ERK and AKT Thr 308, and insensitivity to the effects of dominant negative H-RAS17N mutant.