Indeed, out of 100 randomly selected manuscripts measuring insulin-induced AKT phosphorylation in the hepatoma cell lines that we have read, only seven studies specifically showed AKT phosphorylation at Thr 308, whereas the other 93 either showed only AKT Ser 473 phosphorylation or a non-specified AKT phosphorylation site. This evidence concerns the gene INS and hepatocellular carcinoma.