Considering that CDCA5-high patients had statistically higher mutation burdens in TP53 (Figure 4A, Table 1), this result indicated a potential loss of function correlated with TP53 mutation contributing to the dysregulation of genes involved in p53 pathway, thus promoting the expression of CDCA5 and HCC tumorigenesis. This evidence concerns the gene CDCA5 and hepatocellular carcinoma.