To elucidate the mechanisms underlying SPINK1 upregulation in Enz-resistant PCa cells, we predicted potential targeting miRNAs using the Target Scan and miRmap algorithms, and identified miR-5089-5p, miR-892c-5p and miR-4694-3p as putative candidates (Figure 4A). Here, SPINK1 is linked to posterior cortical atrophy.