A comparison of subgenomic RNA reads predicted from the sequence data (see the supplemental material) suggests that Δ382 viruses may have altered levels of transcription compared to wild-type viruses (Fig. S5), including those of the ORF6 and N genes which are known SARS-CoV interferon (IFN) antagonists (20, –, 23), raising the possibility that infection with Δ382 viruses might result in an altered innate immune response. This evidence concerns the gene IFNA1 and infection.