To explore the association of 4 hub genes (KIF11, CDC20, PBK, TOP2A) and 4 down-regulated DEGs (CDKN1A, PGR, LCN2 and CCNA1) expression with the prognosis of SCA, the survival curves were drawn using Kaplan-Meier plotter database. The gene discussed is PGR; the disease is autosomal dominant cerebellar ataxia.