PIK3CA and cancer: Not only the term of “pathways in cancer (hsa05200)” but also “microRNAs in cancer (hsa05206),” “proteoglycans in cancer (hsa05205),” “PI3K-Akt signaling pathway (hsa04151),” etc., which are associated with cancer and cancer pathophysiological characteristics, were highly enriched in intron only DMGs followed by EI and PI groups (Fig. 4c).