Not only the term of “pathways in cancer (hsa05200)” but also “microRNAs in cancer (hsa05206),” “proteoglycans in cancer (hsa05205),” “PI3K-Akt signaling pathway (hsa04151),” etc., which are associated with cancer and cancer pathophysiological characteristics, were highly enriched in intron only DMGs followed by EI and PI groups (Fig. 4c). This evidence concerns the gene AKT1 and cancer.