As expected, many DMGs that were hypermethylated and downregulated in CMT including TP63, LIFR, PLA2G16, LRIG1, STAT5A, and AKAP12 and have been known as tumor suppressors, were identified from high scoring (OncoScore > 50) CMT-DMRs (Fig. 3b). The gene discussed is LRIG1; the disease is neoplasm.