MMP12 and non-small cell lung carcinoma: Xiao X et al. [40] reported that Oridonin, a diterpenoid compound extracted from traditional medicinal herbs, can inhibit the proliferation, invasion, and migration of gefitinib-resistant non-small cell lung cancer cells by suppressing EGFR/ERK/MMP-12 and CIP2A/PP2A/Akt signaling pathways.