PI4KB (involved in actin formation) [43, 84], SOX2 (essential for early embryonic development) [85] and DPY19L2 (causes infertility by impairing head elongation, PLCζ signalling, acrosome formation and by causing globospermia) [44, 86] were downregulated in crossbred males, in microarray. This evidence concerns the gene SOX2 and Infertility.