In our study, hypermethylation of SNRPN of ZAC1 and hypomethylation of INPP5F accompanied by abnormal gene expressions were observed in CHD with EM cases, suggesting that imprinting aberrations may be an important regulator that causes the abnormal growth and development of embryonic organs, leading to CHD with EM. Here, PLAGL1 is linked to erythema multiforme.