Although eosinophils are present in the granulomas of S mansoni and S japonicum in different proportions, removal of the cell type by administration of anti–IL‐5 antibodies have little effect on granuloma size and fibrosis,72 and eosinophil depletion in mice infected with either S mansoni or S japonicum resulted in slightly smaller granulomas, but had no overall effect on hepatic fibrosis or histology.72, 73. This evidence concerns the gene IL5 and Granuloma.