For example, García-Rivas et al. 22 showed that selective MCU blocker Ru360 (15-50 nmol/kg, i.v.), a RuR analog, given 30 min before ischemia (5 min) followed by reperfusion (5 min), significantly reduced the incidence of arrhythmias and the hemodynamic dysfunctions caused by cardiac CIR in rats. This evidence concerns the gene MCU and ischemia.