CDK5 and Alzheimer disease: Abnormal activities of tau kinases have been associated with AD, including kinases such as Src family kinase, Ca2+/calmodulin-dependent protein kinase II (CaMKII); cyclin-dependent kinase 5 (CDK5); casein kinase (I/II); dual-specificity tyrosine kinase phosphorylation and regulated kinase-1A/2 (DYRK1A/2), glycogen synthase-3 (GSK-3), and tyrosine kinase Fyn [24, 25].