PHF1 and Alzheimer disease: Although the exact mechanism of tauopathy-induced disorders is not yet elucidated, the immunostaining of autopsy brains with anti-p-tau antibodies, including AT8 (pSer202/pThr205), and PHF-1 (pSer396/pSer404) are utilized as a diagnostic method of AD and tauopathy-related diseases [121].