HMOX1 and malaria: On the other hand, Kuesap and colleagues did not find an association between HO-1 polymorphism and disease severity in 329 cases of non-severe malaria (with acute uncomplicated P. falciparum malaria) and 80 cases with P. vivax malaria, and 77 cases with severe or CM for analysis of genetic polymorphisms of HO-1 [80].