CDK5 and myalgic encephalomeyelitis/chronic fatigue syndrome: Another study of cerebrospinal fluid by Schutzer et al (2011) [12] showed differing proteomic profiles between ME/CFS and post-treatment Lyme disease patients that included enrichment in the ME/CFS group of proteins involved in the complement cascade as well as pathways related to CDK5 signaling and dopamine signaling.