APLP1 and myalgic encephalomeyelitis/chronic fatigue syndrome: Baraniuk et al. (2005) [11] found that innate immune and amyloidogenic proteins were detected more frequently in the cerebrospinal fluid of patients compared to controls, and that the presence of one or more of a subset of proteins (α-1-macroglobulin, amyloid precursor-like protein 1, keratin 16, orosomucoid 2, and pigment epithelium-derived factor) predicted ME/CFS status with 80% accuracy.