Moreover, 24-hour treatment of CRC cells with 1 μM of the p38 MAPK activator dehydrocorydaline chloride (DHC) elevated phospho-p38 MAPK and suppressed the levels of p21 and the ratio of LC3B II/I expression in PRDX2 knockdown cells (Figure 5B, 5C and Supplementary Figure 6). This evidence concerns the gene PRDX2 and colorectal carcinoma.