In 2011, Knierim et al. reported a 6‐year‐old female with a diagnosis of FHM1 who presented with recurrent ischemic strokes after minor head trauma, associated with seizures and other neurologic symptoms, who was found to have a novel p.Arg1349Gln variant in CACNA1A. This variant is located in the helical region of the S4 segment in domain III and was hypothesized to be a gain‐of‐function mutation, whereas our patient's variant is in the helical region of the S5 segment in domain IV (Knierim et al., 2011; The UniProt Consortium, 2019; Figure 1a). Here, CACNA1A is linked to ischemic stroke.