While EtOH mice also showed increased anxiety-like behavior in the elevated plus maze during protracted withdrawal, this group difference was eliminated following TMT exposure, as seen in our control drug/virus experiments after BNST norBNI, Pdyn deletion, and mPFC-BNST inhibition, suggesting long-lasting impact of TMT on performance in the elevated plus maze (EPM). Here, PDYN is linked to Anxiety.