Although short‐term contact of acidic bile with HM produced a significant transcriptional activation of NF‐κB‐related genes, similar to prior observation, acidic bile exposure for this period was not capable of up‐regulating Mtor but could induce significant overexpression of Akt1, known factors in head and neck cancer (Figure 3B; Table S2). Here, AKT1 is linked to head and neck cancer.