In addition, it has recently been demonstrated that in vitro concurrent application of a dietary NF‐κB inhibitor such as curcumin with acidic bile sufficiently blocked the acidic bile‐induced tumorigenic effect on hypopharyngeal primary cells, by eliminating NF‐κB activation and preventing the transcriptional activation of molecules central to head and neck cancer.14, 19, 34, 35, 36. Here, NFKB1 is linked to head and neck cancer.