NFKB1 and bile reflux: The novel findings of this in vivo model are in line with previous data from an in vitro model, exploring the effect of curcumin in human hypopharyngeal primary cells, in inhibiting the acidic bile‐induced activation of NF‐κB and its related transcriptional activity,14 and give insights into the prevention and development of effective targeted therapies using non‐pharmacologic NF‐κB inhibitors, in bile reflux‐related early pre‐neoplastic molecular events.