To examine the causative role of the TH1 cell-inducing E. coli 35A1 strain in pathogenesis, we employed the anti-IL10 receptor (IL10R) antibody-mediated colitis model.17 GF wild-type B6 mice were monocolonized with the E. coli 35A1, LF82, or MG1655 strain on day 1, followed by weekly intraperitoneal injections with anti-IL10R antibody. The gene discussed is IL10RA; the disease is colitis.