These experiments revealed that after 16 days, melanoma size increased in the absence of Nav1.8+ sensory nerves (tumour weight increased from 1.05 ± 0.17 to 2.21 ± 0.11 g; tumour weight per body weight increased from 0.06 ± 0.004 to 0.11 ± 0.005 g; tumour area increased from 2.77 ± 0.09 to 4.61 ± 0.10 cm2, tumour volume increased from 1980 ± 264 to 3559 ± 76 mm3; Figure 2B‐F). This evidence concerns the gene SCN10A and melanoma.