Recombinant GDF15 furthermore improved the metabolic phenotype in ob/ob mice (Chung, Ryu, et al., 2017) and inhibited IL‐1β+IFN‐γ‐induced apoptosis of human islets and of a β‐cell line, leading to the prevention of diabetes in NOD mice (Nakayasu et al., 2020). Here, GDF15 is linked to diabetes mellitus.