BRD2 and neoplasm: Although several national guidelines aiming at the standardization of specimen cut up and reporting have been introduced, for example in Australia, Belgium, Germany, the UK, Netherlands, the USA and Hungary, there is no international agreement in the interpretation of tumor regression, in the definition of pCR, and in the measurement of tumor size in cases where fibrosis develops as a result of NAT or multifocality is present [11, 26–31].