In HF, the RyR2 receptors are hyperphosphorylated (Lehnart et al. 2004) and many myofilament proteins (such as cTnI, cMyBP-C, and titin) are hypophosphorylated (Hamdani et al. 2008; Solaro 2008; Solaro and de Tombe 2008) (with an exception of some phospho-sites on titin that become hyperphosphorylated when they are targeted by PKC and CaMKII, two kinases upregulated in HF) (Hamdani et al. 2013b). This evidence concerns the gene PRRT2 and hydrops fetalis.