As adipocytes are a known source of pro-inflammatory cytokines, including TNF-α, IL-1, and IL-6, obesity can be seen as a chronic inflammatory condition (de Almeida et al. 2020; Franssen et al. 2016; Schmidt-Lucke et al. 2015). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.