First, PCNSL are characterized by a high frequency of concomitant MYD88 and CD79B mutations [4] along with lesions related to B-cell development and function (e.g. BLIMP1), and the NF-κB pathway (e.g. CARD11 or TBL1XR1). The gene discussed is NFKB1; the disease is primary central nervous system lymphoma.