In agreement, anti-PD-1 is highly effective in Hodgkin’s lymphoma [43] even though the expression of PD-1 on T-cells is heterogeneous and PD-L1/2 amplification and lack of MHC-I expression on tumoral cells are common, characteristics that should hamper a T-cell mediated response [44]. This evidence concerns the gene CD274 and Hodgkins lymphoma.