ESR1 and neoplasm: In our study, change in CPE during NET was associated with prognosis (on the basis of PEPI) and performed similarly to other mid-treatment predictors of tumor response in ER+/HER2− breast cancer after NAC: change in CPE discriminated PEPI with an AUC of 0.77, and change in apparent diffusion coefficient discriminated pCR with an AUC of 0.76 [11].