CD274 and colorectal cancer: However, clinical trials have shown the clinical effect of anti-PD-L1 antibody alone to be of little benefit, although the number of cases reported was small.35 Recent reports have indicated ICI to be effective in colorectal cancer with high frequency microsatellite instability (MSI-H), known to be present in ~1.5% of all colorectal cancers.36 The instability may be expected to occur in ~2% of PDACs as well, and the effect of ICI may also be expected similarly.