In fact, some reports of radiogenomics have indeed predicted molecular profiles, which are clinically important in breast cancer, lung cancer, and glioblastoma, from image data.10–12 While there are reports predicting clinicopathological results from image data (Radiomics) in pancreatic cancer, there is no such report yet predicting genetic information like p53 and PD-L1 expression.13–16 The current study aimed to predict genetic information simply and inexpensively from images commonly used for cancer diagnosis and treatment. This evidence concerns the gene TP53 and pancreatic neoplasm.