CD8A and neoplasm: Although B16Vax therapeutic treatments lead to higher numbers of CD8+ TILs than TRIMELVax (figure 6D), this non-effective vaccine (figure 4B) lead to the accumulation of a higher proportion of PD-1hi CD8+ T cells, whereas TRIMELVax promoted major proportion of PD-1lo CD8+ T cells in tumors, a phenotype associated with prototypic effector cells required for tumor growth control (figure 6E, F).