IL2 and melanoma: The hu14.18–IL2 IC consists of IL2 fused to the hu14.18 mAb, which targets disialoganglioside D2 (GD2) expressed on the plasma membrane of some melanoma cells.20 In syngeneic mice bearing B78 melanoma tumors, which express GD2, we previously reported that combined treatment with radiotherapy (RT) and intratumor (IT) injection of IC markedly enhanced response compared with RT alone, IC alone, RT +IT-hu14.18 mAb or RT +IV hu14.18–IL2 IC.5 Following this combined treatment with RT and IT-IC, we observed complete resolution of single tumors in 71% of animals.