CD8A and neoplasm: For example, Fransen and colleagues have shown the importance of the tumor-draining lymph node in anti-PD1 therapy in MC38 tumors.63 In addition, pharmacological blocking the egress of lymphocytes from the lymph nodes during PD1 ICB negate the therapeutic effect, showing the critical role of T-cell expansion in the lymph node.63 64 The presence of moDCs was correlated with the effector PD1-CD8+ T-cell population, possibly infiltrating after activation in the lymph nodes.