PDCD1 and melanoma: To further explore the connection between moDCs and the adaptive immune response initiated by PD1 checkpoint blockade further, we analyzed an RNA sequencing data set derived from tumor biopsies of patients with advanced melanoma who were treated with PD1 checkpoint blockade therapy.26 Correlating immune-related gene sets within bulk transcriptomic data, we explored the relationship between genes associated with cell subsets and their activation.