PCa deaths in the UK of were around 11 600 in 2016.2 The global projections of PCa incidence and mortality for 2030 are 1.7 and 0.5 million, respectively.3 The highest incidence of PCa is seen in western societies.4 The significant increase of PCa incidence and diagnosis over the last three decades can be attributed mainly to the widespread implementation of the prostate-specific antigen (PSA serum test after it had been introduced in the late 1980s.5 6. Here, KLK3 is linked to posterior cortical atrophy.