MAPKAPK5 and colorectal carcinoma: To further determine whether the increase in MK5-AS1 staining in patients with CRC was associated with poor prognosis, Kaplan-Meier analysis showed that high levels of MK5-AS1 in the TCGA cohort were associated with decreased overall survival (OS), while high levels of MK5-AS1 in our CRC cohort were associated with overall survival (OS) and relapse-free survival (RFS) (Fig. 1e and f).