EIF2AK2 and Alzheimer disease: The levels of this neurotoxic E3 ubiquitin-protein ligase (Ndrp1) are increased by LPS-induced neuroinflammation [27] which is also under the control of the eukaryotic translation initiation factor 2-alpha kinase 2 (PKR) [28] whose levels are enhanced in AD brains and CSF [29, 30].