Pathway enrichment results of genes with eQTLs suggest that whereas IL-13 may be more of an inducer of immune processes, consistent with the T2 endotype that has a significant allergic component, IL-17A may be more of an inducer of structural changes in ASMCs and subsequent predisposition to AHR, possibly resulting in more refractory asthma, consistent with the Th17 endotype. This evidence concerns the gene IL13 and asthma.