AKT1 and asthma: In support of this idea, many genes are involved in both barrier function and contractile processes, including myosin light chain kinase (MLCK) [57] and members of the Rho family of GTPases Rho and Rac [58, 59], further suggesting that the enrichment of asthma-associated SNPs among BRI-associated SNPs may highlight a set of genes with pleiotropic effects that influence asthma risk through both molecular pathways.