CD274 and neoplasm: RNA-seq data also showed that THZ1 could diminish transcripts of MYC-targeted genes, such as HK2, CDC25A, GLUT1 (SLC2A1), PD-L1 (CD274), BRCA1, and BRCA2 (Fig. 3i), which are important mediators of MYC’s function in tumor metabolism, immune evasion, and DNA repair.