CDK7 and neoplasm: To test the hypothesis that CDK7 could modulate tumor glucose metabolism via suppressing MYC pathway, we found that THZ1 treatment (200 nM, 24 h) inhibited glycolysis via the extracellular acidification rate (ECAR) analysis and suppressed oxidative phosphorylation via oxygen consumption rate (OCR) analysis (Figure S5D) in seahorse metabolic analysis system.