Six targets highly related to the pathological process of TAO, which were sorted according to the node degree, including IL6 (interleukin-6, degree = 262), INS (insulin, degree = 247), TNF (tumor necrosis factor, degree = 242), ALB (serum albumin, degree = 229), AKT1 (RAC-alpha serine/threonine-protein kinase, degree = 221) and TP53 (tumor protein p53, degree = 205) (Table S3). The gene discussed is AKT1; the disease is thromboangiitis obliterans.