Results revealed the prominence of periostin stromal area of cancer, which hence, suggested that at the early stage of mycosis fungoide, there was the dominance of periostin-stimulated macrophages which was responsible for tumor mass formation, while after the plaque stage of cancer, macrophages were dominant for the maintenance of immunosuppressive cancer environment and which gives the therapeutic target for treatment. This evidence concerns the gene POSTN and mycosis fungoides.