Moreover, Marois Giannakis et al. recently identified recurrently mutated genes in CRC, including TP53, KRAS, SMAD4, CTCF, etc., by performing whole-exome sequencing of 619 incident CRCs and integrating the results with tumor immunity, pathology, and survival data [32]. The gene discussed is CTCF; the disease is colorectal carcinoma.