Some common observations involving CTCF function in cancers include the transcriptional activation of TERT, c-MYC, FOXM1, PLK, GAD1 and other genes [14, 22, 24–26] and the transcriptional repression of p53, BCL6, RASSF1A, CDH1 and others [27–30]. The gene discussed is CTCF; the disease is cancer.