The expressions of NF‐κB transcription factor (p50/p65) and IκB in the nucleus and cytoplasm of healthy patients and periodontal tissues were detected by Huang et al. [48], and it has been found that the activation rate of NF‐κB in periodontal tissues (75.90%) was significantly higher than that in normal tissues (5.30%), whereas the expression of IκB periodontal tissues (5%) was significantly lower than that in normal tissues (50%), showing that NF‐κB played an important role in periodontitis. This evidence concerns the gene NFKB1 and periodontitis.