SHARPIN and skin disorder: TNF induced cell death is a driver of the cell death seen in the skin of Sharpincpdm mice as evidenced by the sensitivity of SHARPIN-deficient cells to TNF-induced necroptosis and the lack of dermatitis in TNF-deficient Sharpincpdm mice [15, 16] TNFR1 results in recruitment of LUBAC to a signaling complex that initiates NFkB signaling.