BALB-CMV Sharpin-/-, B6-CMV Sharpin-/-, and Krt14 Sharpin-/- mutant mice developed extensive dermatitis similar to the two spontaneous allelic null mutations, Sharpincpdm/cpdm and Sharpincpdm-Dem/cpdm-Dem with no sexual dimorphism [1, 2]. Here, SHARPIN is linked to skin disorder.