For discrimination between active TB and NoTBI contacts, the combination with the highest AUC (0.87) and accuracy (80.1%) was IP10 + IL7 (Table 3), which presented a better performance than the individual cytokines, although no significant differences (S1 Table) were found (Z = 1.0926, p-value = 0.2746 and Z = 1.5859, p-value = 0.1128 respectively). The gene discussed is IL7; the disease is tuberculosis.