To determine whether the miR-6884-3p/CCNB1 pathway meditated the biological functions of RP11-295G20.2 in Hep3B and MHCC-97H cells, we treated HCC cells with si-RP11-295G20.2 and (or) miR-6884-3p inhibitor. This evidence concerns the gene CCNB1 and hepatocellular carcinoma.