In pan-cancer analysis, PDIA3 indicated worse OS and DSS in adrenocortical carcinoma (ACC), breast invasive carcinoma (BRCA), kidney Chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), lung adenocarcinoma (LUAD), ovarian serous cystadenocarcinoma (OV), pancreatic adenocarcinoma (PAAD), skin Cutaneous Melanoma (SKCM), thyroid carcinoma (THCA), and uveal Melanoma (UVM) (Supplementary Figures 4, 5). The gene discussed is PDIA3; the disease is cancer.