A positive association was observed between PDIA3 expression and various infiltrating immune cell types, which consisted of cells responsible for anti-tumor response such as NK cells, CD4+ T effector memory cells (TEM), CD8+ TEM, and immunosuppressive cells such as DCs, MDSCs, regulatory T cells (Treg), macrophages, mast cells, neutrophils, monocytes (Figure 4C, 4D). Here, CD4 is linked to neoplasm.