Consistent with our findings, the expression of miR-185 was shown to be negatively correlated with POT1 in some kinds of cancers, such as breast cancer, colon and rectal adenocarcinoma, and cutaneous melanoma (http://starbase.sysu.edu.cn/targetSite.php, Pan-Cancer miRNA-Target Pearson Correlation Analysis, r=-0.21796, -0.24041 and -0.10678, respectively, with P<0.05). The gene discussed is POT1; the disease is rectum adenocarcinoma.