Third, IL18 upregulated genes consistent with an effector phenotype that supports growth and proliferation, such as genes related to fatty acid biosynthesis (Dgat2, Scd2, Hacd3) (Ikeda et al., 2008; Cle et al., 2008) and Hif1a, which promotes glycolysis as well as migration of Tregs in glioblastoma (Miska et al., 2019). Here, IL18 is linked to glioblastoma.