Associated with these myofibroblasts are HPCs and ductular reactions, which promote liver fibrosis in part via the conversion of latent pro‐fibrogenic Transforming Growth Factor‐β (TGF‐β) through cholangiocyte expression of Integrins, a large family of transmembrane heterodimers (Iwaisako et al., 2014; Peng et al., 2016). The gene discussed is TGFB1; the disease is Hepatic fibrosis.