Furthermore, while LOXL2 expression in the tumors was unchanged (Supplementary information, Fig. S9a), tumor collagen packing density (Supplementary information, Fig. S9a, b) and lung colonization (Supplementary information, Fig. S9c) were decreased in BAPN-treated LM7-derived OS-bearing mice. This evidence concerns the gene LOXL2 and neoplasm.