Screening regulators and downstream effectors, we demonstrate that Wnt9a and Wnt7b are two novel c-Fos/AP-1 target genes operating in an autocrine, and possibly paracrine, fashion to induce Loxl2 expression, thereby modulating collagen packing and impacting on osteoblast differentiation and tumor pathology. The gene discussed is JUNB; the disease is neoplasm.