The Wnt/β-catenin target genes Axin2, c-myc and Ccnd1 were also significantly decreased in WlsΔOB-OS tumor-bearing bones (Fig. 1b) and primary OS cells (Supplementary information, Fig. S1a), while endogenous c-fos and the c-fos transgene were not affected. This evidence concerns the gene AXIN2 and neoplasm.