SOST and neoplasm: Importantly, the osteoblast transcription factor Sp7, encoding Osx, and the late-osteoblast/osteocyte maker Sost, encoding Sclerostin, were significantly decreased in tumor-bearing bones from WlsΔOB-OS mice, while the decrease in Bglap mRNA, encoding the mature osteoblast marker Osteocalcin, did not reach statistical significance (Fig. 2c).