Of note, none of the abovementioned correlations between EGFR, FOS, WNT7B/WNT9A and LOXL2 expression was observed, when examining 27 chondrosarcoma (CS) patient samples that were included in the US Biomax TMA (Supplementary information, Fig. S11, Table 1 and data not shown), indicating that our findings are likely specific to OS. This evidence concerns the gene LOXL2 and Cowden syndrome 1.