LAG3 and neoplasm: The expression of LAG3 and HAVCR2 also exhibited significant positive associations with intratumoral TILs (Supplementary information, Fig. S9a), and immunofluorescence analysis confirmed the higher percentage of LAG-3+ and HAVCR2+ CD8+ T cells in the total CD8+ T cells in tumor epithelial nests compared with those in the tumor stroma (Supplementary information, Fig. S9b).