Interestingly, NK cells shared upregulated expression patterns of TFs such as EOMES, RUNX3, and XBP1 with cytotoxic CD8+ T cell subtypes (Fig. 4i), indicating the potential roles of these TFs in regulating the cytotoxic activity of both CD8+ T and NK cells in NPC. The gene discussed is RUNX3; the disease is nasopharyngeal carcinoma.